PI-3-kinases

PI-3-kinases
(= phosphatidyl inositol-3-kinases; PI kinases)
Lipid kinases that phosphorylate phosphatidylinositol phosphate on the 3 position.Now recognised to be key enzymes acting downstream of many receptors, particularly receptor tyrosine kinases such as PDGF-receptor (in the case of Class Ia). Classical form has p85 regulatory subunit and p110 enzymatic subunit. The p85 adaptor associates with the cytoplasmic domain of various growth factor receptors through SH2 domains that bind to phosphotyrosine residues in the ligated (phosphorylated) receptor and with the catalytic subunit. An increasing family is being identified, some of which are regulated by G-proteins or calcium. Most are inhibited by wortmannin

Dictionary of molecular biology. 2004.

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